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1

Architecture of the streptomyces lividans DnaA protein-replication origin complexes

Dagmara Jakimowicz, Jerzy Majka, Grażyna Konopa, Grzegorz Wȩgrzyn, Walter Messer, Hildgund Schrempf, Jolanta Zakrzewska-Czerwińska

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 513 KB

english, 2000

2

Changes in hair morphology of mucopolysaccharidosis I patients treated with recombinant human α-L-iduronidase (laronidase, Aldurazyme)

Anna Kloska, Jerzy Bohdanowicz, Grażyna Konopa, Anna Tylki-Szymńska, Joanna Jakóbkiewicz-Banecka, Barbara Czartoryska, Anna Liberek, Alicja Węgrzyn, Grzegorz Węgrzyn

Journal:

American Journal of Medical Genetics Part A

Year:

2005

Language:

english

File:

PDF, 232 KB

english, 2005

3

ChemInform Abstract: Synthesis and Reactivity of 5,8-Dihydroxythioflavanone Derivatives.

Marek T. Konieczny, Barbara Horowska, Antoni Kunikowski, Jerzy Konopa, Konstanty Wierzba, Yuji Yamada, Tetsuji Asao

Journal:

Year:

1999

File:

PDF, 34 KB

1999

4

ChemInform Abstract: Synthesis of Polyhydroxylated Derivatives of Phenyl Vinyl Sulfone as Structural Analogues of Chalcones.

Marek T. Konieczny, Barbara Horowska, Antoni Kunikowski, Jerzy Konopa, Konstanty Wierzba, Yuji Yamada, Tetsuji Asao

Journal:

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

5

ChemInform Abstract: Antitumor Acridines with Diaminoalkylo Pharmacophoric Group

Journal:

Year:

2002

File:

PDF, 24 KB

2002

6

The products of electro- and photochemical oxidation of 2-hydroxyacridinone, the reference compound of antitumor imidazoacridinone derivatives

Zofia Mazerska, Silvia Zamponi, Roberto Marassi, Paweł Sowiński, Jerzy Konopa

Journal:

Journal of Electroanalytical Chemistry

Year:

2002

Language:

english

File:

PDF, 286 KB

english, 2002

7

Electrochemical oxidation of antitumor imidazoacridinone derivatives and the reference 2-hydroxyacridinone

Zofia Mazerska, Silvia Zamponi, Roberto Marassi, Sante Martelli, Jerzy Konopa

Journal:

Journal of Electroanalytical Chemistry

Year:

1997

Language:

english

File:

PDF, 966 KB

english, 1997

8

Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311

Anna Skwarska, Ewa Augustin, Jerzy Konopa

Journal:

Year:

2007

Language:

english

File:

PDF, 603 KB

english, 2007

9

Synthesis and 1H NMR characterization of substituted 1-amino-9-imino-4-nitro-9,10-dihydr oacridines as potential antitumor agents

Wieslaw M. Cholody, Jerzy Konopa, Ippolito Antonini, Sante Martelli

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 442 KB

1991

10

Synthesis of substituted 1,4-diazepino[5,6,7-kl]acridines and imidazo[4,5,1-de][1,4]diazepino[5,6,7-mn]acridines

Wieslaw M. Cholody, Jerzy Konopa, Sante Martelli

Journal:

Journal of Heterocyclic Chemistry

Year:

1992

File:

PDF, 320 KB

1992

11

The mode of action of cytotoxic and antitumor 1-nitroacridines. III. In vivo interstrand cross-linking of DNA of mammalian or bacterial cells by 1-nitroacridines

Jerzy Konopa, Jan W. Pawlak, Katarzyna Pawlak

Journal:

Chemico-Biological Interactions

Year:

1983

Language:

english

File:

PDF, 1.38 MB

english, 1983

12

The mode of action of cytotoxic and antitumor 1-nitroacridines. I. The 1-nitroacridines do not exert their cytotoxic effects by physicochemical binding with DNA

Katarzyna Pawlak, Andrzej Matuszkiewicz, Jan W. Pawlak, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1983

Language:

english

File:

PDF, 1009 KB

english, 1983

13

The mode of action of cytotoxic and antitumor 1-nitroacridines. II. In vivo enzyme-mediated covalent binding of a 1-nitroacridine derivative, ledakrin or nitracrine, with DNA and other macromolecules of mammalian or bacterial cells

Jan W. Pawlak, Katarzyna Pawlak, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1983

Language:

english

File:

PDF, 1.42 MB

english, 1983

14

DNA damage in HeLa S3 cells by an antitumor drug ledakrin and other antitumor 1-nitro-9-aminoacridines

Jan M. Woynarowski, Agnieszka Bartoszek, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1984

Language:

english

File:

PDF, 1008 KB

english, 1984

15

32P-postlabelling analysis of adducts formed by mitoxantrone and ametantrone with DNA and homopolydeoxyribonucleotides after enzymatic activation

Pawel Dackiewicz, Andrzej Skladanowski, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 1.24 MB

english, 1995

16

Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells

Magdalena Hyzy, Przemyslaw Bozko, Jerzy Konopa, Andrzej Skladanowski

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 499 KB

english, 2005

17

Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305

Ewa Augustin, Anna Moś-Rompa, Anna Skwarska, Jacek M. Witkowski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 991 KB

english, 2006

18

Antitumor 1-nitroacridine derivative C-1748, induces apoptosis, necrosis or senescence in human colon carcinoma HCT8 and HT29 cells

Ewa Augustin, Anna Moś-Rompa, Dorota Nowak-Ziatyk, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.31 MB

english, 2010

19

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Anita Wiśniewska, Magdalena Niemira, Karolina Jagiełło, Agnieszka Potęga, Małgorzata Świst, Colin Henderson, Anna Skwarska, Ewa Augustin, Jerzy Konopa, Zofia Mazerska

Journal:

Biochemical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

20

Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells?

Andrzej Skladanowski, Marcin Koba, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 191 KB

english, 2001

21

Enzymatic activation of a new antitumour drug, 5-diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311, observed after its intercalation into DNA

Zofia Mazerska, Jaroslaw Dziegielewski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 422 KB

english, 2001

22

Intercalation of imidazoacridinones to DNA and its relevance to cytotoxic and antitumor activity

Jarosław Dzięgielewski, Bartłomiej Ślusarski, Antoni Konitz, Andrzej Składanowski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 263 KB

english, 2002

23

Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug, C-1311

Zofia Mazerska, Paweł Sowiński, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 298 KB

english, 2003

24

32P-Post-labelling analysis of nucleobases involved in the formation of DNA adducts by antitumor 1-nitroacridines

Agnieszka Bartoszek, Paweł Dackiewicz, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1997

Language:

english

File:

PDF, 865 KB

english, 1997

25

In vitro DNA crosslinking by Ledakrin, an antitumor derivative of 1-nitro-9-aminoacridine

Agnieszka Bartoszek, Paweł Dackiewicz, Andrzej Składanowski, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

26

The relevance of enzymatic oxidation by horseradish peroxidase to antitumour potency of imidazoacridinone derivatives

Zofia Mazerska, Katarzyna Gorlewska, Agnieszka Kraciuk, Jerzy Konopa

Journal:

Chemico-Biological Interactions

Year:

1998

Language:

english

File:

PDF, 326 KB

english, 1998

27

Adriamycin and daunomycin induce interstrand DNA crosslinks in HeLa S3 cells

Journal:

Biochemical and Biophysical Research Communications

Year:

1983

Language:

english

File:

PDF, 437 KB

english, 1983

28

In vitro binding of metabolically activated [14C]-Ledakrin, or 1-nitro-9-14C-(3′-dimethylamino-n-propylamino) acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular fractions isolated from rat liver and HeLa cells

Jan W. Pawlak, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 1.27 MB

english, 1979

29

Induction of deoxyribonucleic acid damage in HeLa S3 cells by cytotoxic and antitumor sesquiterpene lactones

Jan W. Woynarowski, Terry A. Beerman, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 338 KB

english, 1981

30

Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes

Andrzej Witkowski, Barbara Woynarowska, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 895 KB

english, 1984

31

32P-post-labelling analysis of DNA adducts formed by antitumor 1-nitro-9-aminoacridines with DNA of HeLa S3 cells

Agnieszka Bartoszek, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 930 KB

english, 1987

32

G2 block induced by DNA crosslinking agents and its possible consequences

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 708 KB

english, 1988

33

32P-post-labeling analysis of DNA adduct formation by antitumor drug nitracrine (ledakrin) and other nitroacridines in different biological systems

Agnieszka Bartoszek, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 2.57 MB

english, 1989

34

Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells

Jan M. Woynarowski, Helen McNamee, Leszek Szmigiero, Terry A. Beerman, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 675 KB

english, 1989

35

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

Andrzej Skladanowski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.52 MB

english, 1993

36

Relevance of interstrand DNA crosslinking induced by anthracyclines for their biological activity

Andrzej Skladanowski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.11 MB

english, 1994

37

Interstrand DNA crosslinking induced by anthracyclines in tumour cells

Andrzej Skladanowski, Jerzy Konopa

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.15 MB

english, 1994

38

Products of Metabolic Activation of the Antitumor Drug Ledakrin (Nitracrine) in Vitro

Gorlewska, Katarzyna, Mazerska, Zofia, Sowiński, Paweł, Konopa, Jerzy

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001

39

Synthesis and Reactivity of 5,8-Dihydroxythioflavanone Derivatives

Konieczny, Marek T., Horowska, Barbara, Kunikowski, Antoni, Konopa, Jerzy, Wierzba, Konstanty, Yamada, Yuji, Asao, Tetsuji

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

40

8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity

Cholody, Wieslaw M., Martelli, Sante, Konopa, Jerzy

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 737 KB

english, 1990

41

Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias

Cholody, Wieslaw M., Martelli, Sante, Konopa, Jerzy

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 710 KB

english, 1992

42

Binding of the cytotoxic and antitumor triterpenes, cucurbitacins, to glucocorticoid receptors of Hela cells

Witkowski, Andrzej, Konopa, Jerzy

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1981

Language:

english

File:

PDF, 634 KB

english, 1981

43

5-[(Aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic agents. Synthesis and biological activity

Cholody, Wieslaw M., Martelli, Sante, Paradziej-Lukowicz, Jolanta, Konopa, Jerzy

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 563 KB

english, 1990

44

Structure−Activity Relationship for Antineoplastic Imidazoacridinones: Synthesis and Antileukemic Activity in Vivo

Cholody, Wieslaw M., Horowska, Barbara, Paradziej-Lukowicz, Jolanta, Martelli, Sante, Konopa, Jerzy

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 167 KB

english, 1996

45

Coordination and peri -Carbon Metalation of 1-Nitro-9-[(2-aminoethyl)amino]acridines toward Platinum(II). Evidences for Hydrogen Bonding between Endocyclic N(10)H and Chloride Ion

Ceci, Edmondo, Cini, Renzo, Konopa, Jerzy, Maresca, Luciana, Natile, Giovanni

Journal:

Inorganic Chemistry

Year:

1996

Language:

english

File:

PDF, 233 KB

english, 1996

46

Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis

Paradziej-Łukowicz, Jolanta, Skwarska, Anna, Peszyńska-Sularz, Grażyna, Brillowska-Dąbrowska, Anna, Konopa, Jerzy

Journal:

Cancer Biology & Therapy

Year:

2011

Language:

english

File:

PDF, 4.18 MB

english, 2011

47

Isolation of Viscotoxins. Cytotoxic Basic Polypeptides from Viscum album L.

KONOPA, Jerzy, WOYNAROWSKI, Jan Michał, LEWANDOWSKA-GUMIENIAK, Małgorzata

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1980

Language:

english

File:

PDF, 1.21 MB

english, 1980

48

Interaction Between DNA and Viscotoxins. Cytotoxic Basic Polypeptides from Viscum album L.

WOYNAROWSKI, Jan Michał, KONOPA, Jerzy

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1980

Language:

english

File:

PDF, 1.26 MB

english, 1980

49

Synthesis of Polyhydroxylated Derivatives of Phenyl Vinyl Sulfone as Structural Analogs of Chalcones

Konieczny, Marek T., Horowska, Barbara, Kunikowski, Antoni, Konopa, Jerzy, Wierzba, Konstanty, Yamada, Yuji, Asao, Tetsuji

Journal:

Year:

2001

Language:

english

File:

PDF, 69 KB

english, 2001

50

Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer

Tadi, Kiranmayi, Ashok, Badithe T., Chen, Yuangen, Banerjee, Debabrata, Wysocka-Skrzela, Barbara, Konopa, Jerzy, Darzynkiewicz, Zbigniew, Tiwari, Raj K.

Journal:

Cancer Biology & Therapy

Year:

2007

Language:

english

File:

PDF, 576 KB

english, 2007